recipient mice Search Results


immunodeficient severe combined immunodeficient (scid) balb/c recipient mice  (Harlan Winkelmann)
90
Harlan Winkelmann immunodeficient severe combined immunodeficient (scid) balb/c recipient mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Immunodeficient Severe Combined Immunodeficient (Scid) Balb/C Recipient Mice, supplied by Harlan Winkelmann, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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icr (recipient) mice  (Japan SLC inc)
90
Japan SLC inc icr (recipient) mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Icr (Recipient) Mice, supplied by Japan SLC inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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scid/balb/c recipient mice  (Harlan Winkelmann)
90
Harlan Winkelmann scid/balb/c recipient mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Scid/Balb/C Recipient Mice, supplied by Harlan Winkelmann, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bd-recipient mice  (Becton Dickinson)
90
Becton Dickinson bd-recipient mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Bd Recipient Mice, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mononuclear cells of hematopoietic tissues of gata-1.05 /x mice and recipient nude mice  (clea japan inc)
90
clea japan inc mononuclear cells of hematopoietic tissues of gata-1.05 /x mice and recipient nude mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Mononuclear Cells Of Hematopoietic Tissues Of Gata 1.05 /X Mice And Recipient Nude Mice, supplied by clea japan inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mononuclear cells of hematopoietic tissues of gata-1.05 /x mice and recipient nude mice - by Bioz Stars, 2026-06
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recipient mice  (Jackson Laboratory)
86
Jackson Laboratory recipient mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Recipient Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recipient mice - by Bioz Stars, 2026-06
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recipient balb c mice  (Human Metabolome Technologies America)
86
Human Metabolome Technologies America recipient balb c mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Recipient Balb C Mice, supplied by Human Metabolome Technologies America, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recipient mice  (Exosome Diagnostics)
86
Exosome Diagnostics recipient mice
Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in <t>SCID</t> BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.
Recipient Mice, supplied by Exosome Diagnostics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in SCID BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.

Journal: Molecular cancer therapeutics

Article Title: Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

doi: 10.1158/1535-7163.MCT-08-0444

Figure Lengend Snippet: Inhibition of in vivo NSCLC growth by expression of dnFGFR1. Tumor formation of SCC-derived VL-8 and adenocarcinoma-derived A427 cells transduced with GFP or dnFGFR1 adenoviruses were analyzed by s.c. implantation in SCID BALB/c mice. Forty-nine days after s.c. injection, the mice were killed and the tumors were isolated and further analyzed. Photographs of representative tumors are shown (A, top). Tumor volumes (A, bottom) were calculated as described in Materials and Methods. Each experimental group contained three to six animals. Mean ± SD. Significant differences to controls were determined by two-way ANOVA with Bonferroni post-test. Formalin-fixed A427-derived tumor specimens were routinely processed for paraffin embedding, and sections were stained with pan-cytokeratin (B) or H&E and Ki-67 (D) as indicated. B, controltumors grew in an infiltrative manner, with a jagged and fissured margin and a high frequency of isolated tumor islets invading the surrounding stroma. In contrast, dnFGFR1-expressing tumors grew in a more encapsulated fashion and exhibited stronger compression of the surrounding stromal tissue (arrows). Boxed regions (top) are shown at higher magnifications (bottom). C, mitotic (left) and apoptotic (right) cells were counted in viable boundary regions of H&E-stained tumor sections. D, apoptotic cells were counted in at least 10 small prenecrotic (top, H/E stain) and Ki-67-negative (bottom) regions as representatively shown (right). Bar, 50 μm (B, bottom) and 100 μm (B, top, and D). Columns, mean of at least 15 optical fields (C) or 10 regions (D) analyzed; bars, SD. Significant differences to controls were determined by Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.0001.

Article Snippet: Subsequently, 1 × 10 6 cells in 50 μ L PBS were s.c. injected into the rear flanks of immunodeficient severe combined immunodeficient (SCID) BALB/c recipient mice (female, ages 4 weeks; Harlan Winkelmann).

Techniques: Inhibition, In Vivo, Expressing, Derivative Assay, Transduction, Injection, Isolation, Staining